Modeling of extemporaneous oral suspensions from nystatin tablets

Abstract

In geriatrics and pediatrics, the production of extemporary liquid and solid drugs of individualized concentration from tablets is important in order to facilitate the use of medicines by patients, i.e. facilitate the dosage, method of administration, mask the unpleasant taste and smell of the medicinal substance with the help of auxiliary substances. Industrial production liquid suspensions with nystatin as an active substance for the treatment of symptoms of fungal infections and candidiasis are not registered in the Register of Medicinal Products in Lithuania. They can only be purchased for extemporal production. Therefore, it is relevant to look for ways to model modern, attractive for the patient to take a liquid drug from nystatin tablets, the need for which has remained for the treatment and improvement of candidiasis and other fungal infectious conditions. For this it is necessary to apply auxiliary substances.

Research methodology: Suspensions from nystatin tablets are produced by the method of mechanical dispersing. Suspensions are produced by the mass - volume method, applying the methodology for the production of suspensions of hydrophobic substances.

The quality of extemporal modeled drugs was evaluated after the following studies: the rate and extent of sedimentation; resuspending; organoleptic properties.

The results of the study. To stabilize extemporal medicinal suspensions with nystatin, it is recommended to use a 1% solution of hypromellose during production. When using this solution, the sedimentation of the suspension is very slow, so it is possible to accurately dose the medicinal substance. Modeled oral suspensions of extemporal production with nystatin from tablets met the applicable quality requirements, production schemes can be applied for extemporaneous production in pharmacies.